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Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors

机译：氨基糖甙类和mdm2抑制剂联合应用对无义突变肿瘤抑制因子p53的协同作用

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Meiqiongzi Zhang; Angelos Heldin; Mireia Palomar-Siles; Susanne Öhlin; Vladimir J. N. Bykov; Klas G. Wiman;
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1. Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors [J] . Meiqiongzi Zhang, Angelos Heldin, Mireia Palomar-Siles, Frontiers in Oncology . 2017 ,第4期

机译：通过用氨基糖苷和MDM2抑制剂的组合治疗协同抑制无意义突变肿瘤抑制器P53
2. Synergistic Anti-Leukemic Activity with Combination of FLT3 Inhibitor Quizartinib and MDM2 Inhibitor Milademetan in FLT3-ITD Mutant/p53 Wild-Type Acute Myeloid Leukemia Models [J] . Andreeff Michael, Zhang Weiguo, Kumar Prasanna, Blood: The Journal of the American Society of Hematology . 2018 ,第NovaelaTreatmentAppr期

机译：协同抗白血病活性与FLT3抑制剂Quizartinib和MDM2抑制剂MILADEMETAN组合FLT3-ITD突变体/ P53野生型急性髓鞘白血病模型
3. Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin. [J] . Hay T, Matthews JR, Pietzka L, Cancer research: The official organ of the American Association for Cancer Research, Inc . 2009 ,第9期

机译：聚（ADP-核糖）聚合酶-1抑制剂治疗与卡铂联合可在体内消退自发性Brca2 / p53突变乳腺肿瘤，并延迟肿瘤复发。
4. Low Threshold of Destabilization for Loss of Tumor Suppressor Activity of p53: A Quantitative Analysis of p53 Tetramerization Domain Mutants [C] . Rui Kamada, Takao Nomura, Yoshiro Chuman Japanese peptide symposium . 2011

机译：P53肿瘤抑制剂损失损失低阈值的稳定性：P53四聚化结构域突变体的定量分析
5. Crystal structures of oncogenic, suppressor and rescued p53 core domain mutants suggest the rescue mechanisms of global suppressor mutations [D] . Wang, Ying 2007

机译：致癌，抑制和挽救的p53核心域突变体的晶体结构表明了整体抑制突变的挽救机制
6. Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors [O] . Meiqiongzi Zhang, Angelos Heldin, Mireia Palomar-Siles, 2017

机译：氨基糖苷类和Mdm2抑制剂联合治疗对无意义的突变型肿瘤抑制子p53的协同抢救。
7. Association of p19ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53 [O] . R. Honda 1999

机译：P19ARF与MDM2的关联抑制MDM2的泛素连接酶活性P53
8. Regulation of IAP (Inhibitor of Apoptosis) Gene Expression by the p53 Tumor Suppressor Protein. [R] . Murphy, M. E. 2005

机译：p53肿瘤抑制蛋白调节Iap（细胞凋亡抑制因子）基因表达。

Synergistic Rescue of Nonsense Mutant Tumor Suppressor p53 by Combination Treatment with Aminoglycosides and Mdm2 Inhibitors

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